Plumbagin alleviates obesity‐related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway

Abstract Background Obesity‐related asthma, a specific type of tends to have more severe symptoms and frequent exacerbations, it is insensitive standard medications. Plumbagin (PLB) has many positive effects on human health. However, remains unclear whether PLB protects against obesity‐related asthma. The study investigated the effect Methods Four‐week‐old male C57BL6/J mice were fed either standard‐chow diet or high‐fat (HFD). sensitized 100 μg ovalbumin (OVA) once week intraperitoneally injected with 1 mg/kg daily from Week 10 11 then challenged OVA twice day 12. lung tissue bronchoalveolar lavage fluid (BALF) collected 48 h after first challenge. Results HFD enhanced inflammatory cell infiltration within airways increased total eosinophil counts, levels eosinophil‐related cytokines, including interleukin‐4 (IL‐4), IL‐5, eotaxin in BALF, oxidative stress tissues asthmatic mice. reduced airway walls, cytokines obese In addition, restored HFD‐induced decreases adenosine monophosphate‐activated protein kinase (AMPK) phosphorylation. Conclusion suggested that exacerbated inflammation stress, while probably alleviated activated AMPK pathway attenuate obesity‐associated Thus, likely had potential treat